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KMID : 0617320010100010132
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Journal of Pharmacetical Sceiences Ewha Womans University
2001 Volume.10 No. 1 p.132 ~ p.136
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Resveratrol Analog, 3,5,2´,4´-Tetramethoxy-trans-stilbene, Potentiates the Inhibition of Cell Growth and Induces Apoptosis in Human Cancer Cells
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Nam, Kyung Ae
Kim, Sanghee/Heo, Yoen Hoi/Lee, Sang Kook
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Abstract
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Resveratrol, a trihydroxystilbene found in grapes and several plants, has been shown to bbe active in inhibiting multistage carcinogenic process. using resveratrol as the prototype, we synthesized several analogs and evaluated their growth inhibitory effect using cultured human cancer cells. In the present report we show that one of the resveratrol analogs, 3,5,2´,4´-tetramethoxy-trans-stilbene, potentiated the inhibition of cancer cell growth. Prompted by the strong growth inhibitory activity of the compound(IC_50; 0.8㎍/ml) compared to resveratrol(IC_50; 18.7㎍/ml) in cultured human colon cancer cells(Col2), we performed an action mechanism study using the compound. the compound induced the accmulation of cellular DNA contents in the sub-G0 phase DNA contents of the cell cycle by in a time-dependent manner. The morphological changes were also consistent with an apoptotic process. This result indicated that the compound induced apoptosis of cancer cells, and may be a candidate for use in the development of potential cancer chemotherapeutic or cancer chemopreventive agents.
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